In vivo effects of glucocorticoids on IgE production

摘要: Abstract Recent in vitro investigations have demonstrated that corticosteroids combination with interleukin-4 induce the synthesis of IgE. Corticosteroids are increasingly being used to treat inflammatory component asthma. This has raised concern over potential vivo effects on IgE production and correlation IgE-enhancing clinical In this study 10 patients asthma were given a 7-day course 20 mg prednisone, administered orally two times day. All had rise serum levels after prednisone (p = 0.005). Detection specific pollen perennial allergens was polyclonal. Peripheral blood mononuclear cells from treated produced increased when exogenous IL-4 added their cultures. obtained before administration revealed significant decrease interferon-γ 0.005), but not 0.6), prednisone. These findings paralleled by frequency 0.03), 1.0) expressing cells. Despite increase synthesis, there forced expiratory volume 1 second 0.01). data suggest observed associated treatment is clinically deleterious reflects immunomodulatory T lymphocytes. (J ALLERGYCLINIMMUNOL1994;94:222-30.)