Relaxation of coronary arteries by electro-mechanical decoupling or adrenergic stimulation.

摘要: The contractions of isolated spiral strips from bovine and porcine coronary arteries were induced by potassium depolarization. preparations relaxed verapamil and/or isoproterenol. 1. The non-activated preparation artery has a basal tone corresponding to 15±1.7% the maximum developed tension. 2. The contraction depolarization was largely prevented 11.3 μg/ml verapamil. In this preparation, however, 2.8 noradrenaline depolarized strip same degree as compared with values polarized arteries. 3. The depolarized, activated is more inhibition calcium ion influx (verapamil) than activation beta-adrenergic receptors (isoproterenol). relaxing effect takes place in following order: (51.7%) < isoproterenol (86.1%) (100%). 4. The polarized, stimulation (isoproterenol) (verapamil). (64.4%) (85.3%) (100%). 5. The maximal relaxation after verapamil, noradrenaline, or increases augmented fibre stretch.