Biocompatible and Biodegradable Electrospun Nanofibrous Membranes Loaded with Grape Seed Extract for Wound Dressing Application

摘要: The development of nanofibrous membranes with tunable wettability, degradation, and biocompatibility is highly keen for biomedical applications, including drug delivery wound dressing. In this study, biocompatible biodegradable antioxidant properties were successfully prepared by the electrospinning technique. developed using polylactic acid (PLA) polyethylene oxide (PEO) as matrix, addition grape seed extract (GSE), a rich source natural antioxidants. thoroughly characterized both from materials point view. PLA PLA/PEO nanofibers showed high encapsulation efficiency, close to 90%, while encapsulated GSE retained its capacity in membranes. vitro release studies that diffuses PLA/GSE PLA/PEO/GSE Fickian diffusion manner, whose experimental data well fitted Korsmeyer-Peppas model. Furthermore, higher controlled was observed membrane. Moreover, culturing experiments human foreskin fibroblast (HFF1) cells demonstrated all samples are GSE-loaded support better cell attachment proliferation compared membranes, owing superior hydrophilicity. summary, results suggested promising topical system have great potential dressing applications.