Association of food allergy and decreased lung function in children and young adults with asthma

摘要: Abstract Background Food allergy (FA) appears early in the atopic march, a progression that may lead to development of asthma. The association between FA and pulmonary function children with without asthma remains unknown. Objective To investigate lung Methods We enrolled 1,068 as part family-based cohort. then categorized having by physician diagnosis, evidence specific IgE, typical symptoms within 2 hours food ingestion. diagnosis. used American Thoracic Society criteria for spirometry measurements. assessed effects classification number on using mixed-effect models. Results children: 417 (39%) had asthma, 402 (38%) at least 1 FA, 162 (15%) or more FAs. Unstratified analyses found no significant function. In we detected statistically differences predicted forced expiratory flow 25% 75% FAs compared those none (mean [SE] β = −7.5 [3.6]; P = .04). This effect lost significance after adjusting aeroallergen sensitization. associations volume second, vital capacity, ratio second capacity. Conclusion Having is potential risk factor greater small airway airflow obstruction among highlighting need close clinical follow-up improved intervention strategies these patients.