Primary ovarian neuroendocrine tumor arising in association with a mature cystic teratoma: A case report.

摘要: Primary ovarian carcinoid tumors are exceptionally rare entities accounting for approximately 0.1% of all neoplasms. This report describes a primary neuroendocrine tumor arising in association with mature cystic teratoma 65 year-old woman. Macroscopically, the unilateral adnexal was composed cystic, solid and mucinous elements which resolved into dual component lesion histologically. The majority displayed an organoid architecture mild to moderate pleomorphism no discernible mitotic activity, while 10% consisted sheets groups cells highly pleomorphic nuclei, necrosis occasional mitoses. Features were seen very focally. Immunohistochemistry revealed strong, diffuse positivity CD56 synaptophysin. Chromogranin immunonegativity noted there absence nuclear β-catenin accumulation. Ki-67 index 10–12%. Although is established diagnostic framework tumors, this case diagnosed as well-differentiated tumor, Grade 2 (intermediate grade), teratoma/dermoid cyst. highlights need develop criteria area.