Replenishing Peripheral CD4(+) Regulatory T Cells: A Possible Immune-Intervention Strategy in Type 1 Diabetes?
作者： Charles Sia
关键词:
摘要: Controlling the diabetogenic activity of peripheral islet antigen-specific T cells is essential to halt progression autoimmunity that leads development type 1 diabetes mellitus (T1DM). Over past years, evidence has been gathered suggest dysfunction CD4(+)CD25(+) regulatory (Treg) cells, and interleukin-10 (IL10) -secreting (Tr1) are associated with disease onset in diabetic patients. Although Treg develop as a distinct lineage thymus, results from recent studies have shown they can also arise independently pool conventional CD4(+) lymphocytes. These observations led various methods convert into Tr1 vitro or induce expansion cell subsets vivo. This article reviews progress made recruitment vivo involves potential for prevention even reversal T1DM.
diabeticstudies.org参考文章(45)
Mireia Sospedra, Ricardo Pujol-Borrell, Xavier Ferrer-Francesch, Manel Juan, Màrius Foz-Sala, Orlando Domínguez, Transcription of a Broad Range of Self-Antigens in Human Thymus Suggests a Role for Central Mechanisms in Tolerance Toward Peripheral Antigens Journal of Immunology. ,vol. 161, pp. 5918- 5929 ,(1998)
J L Hurwitz, E Herber-Katz, W Gerhard, C J Hackett, Characterization of the murine TH response to influenza virus hemagglutinin: evidence for three major specificities. Journal of Immunology. ,vol. 133, pp. 3371- 3377 ,(1984)
Clare Baecher-Allan, Julia A. Brown, Gordon J. Freeman, David A. Hafler, CD4+CD25high Regulatory Cells in Human Peripheral Blood Journal of Immunology. ,vol. 167, pp. 1245- 1253 ,(2001) , 10.4049/JIMMUNOL.167.3.1245
Bart O. Roep, The role of T-cells in the pathogenesis of Type 1 diabetes: from cause to cure. Diabetologia. ,vol. 46, pp. 305- 321 ,(2003) , 10.1007/S00125-003-1089-5
Jeffrey D. Price, Jessica Schaumburg, Charlotta Sandin, John P. Atkinson, Gunnar Lindahl, Claudia Kemper, Induction of a Regulatory Phenotype in Human CD4+ T Cells by Streptococcal M Protein Journal of Immunology. ,vol. 175, pp. 677- 684 ,(2005) , 10.4049/JIMMUNOL.175.2.677
Leonie S. Taams, Milica Vukmanovic-Stejic, Jay Smith, Padraic J. Dunne, Jean M. Fletcher, Fiona J. Plunkett, Saskia B. Ebeling, Giovanna Lombardi, Malcolm H. Rustin, Johannes W. J. Bijlsma, Floris P. J. G. Lafeber, Mike Salmon, Arne N. Akbar, Antigen-specific T cell suppression by human CD4+CD25+ regulatory T cells. European Journal of Immunology. ,vol. 32, pp. 1621- 1630 ,(2002) , 10.1002/1521-4141(200206)32:6<1621::AID-IMMU1621>3.0.CO;2-Q
Leigh A. Stephens, Christian Mottet, Don Mason, Fiona Powrie, Human CD4(+)CD25(+) thymocytes and peripheral T cells have immune suppressive activity in vitro. European Journal of Immunology. ,vol. 31, pp. 1247- 1254 ,(2001) , 10.1002/1521-4141(200104)31:4<1247::AID-IMMU1247>3.0.CO;2-M
Ethan M Shevach, Mary Collins, Michael C Byrne, Rebecca S McHugh, Matthew J Whitters, Ciriaco A Piccirillo, Deborah A Young, CD4+CD25+ Immunoregulatory T Cells: Gene Expression Analysis Reveals a Functional Role for the Glucocorticoid-Induced TNF Receptor Immunity. ,vol. 16, pp. 311- 323 ,(2002) , 10.1016/S1074-7613(02)00280-7
Shohei Hori, Takashi Nomura, Shimon Sakaguchi, Control of Regulatory T Cell Development by the Transcription Factor Foxp3 Science. ,vol. 299, pp. 1057- 1061 ,(2003) , 10.1126/SCIENCE.1079490
Petros Vafiadis, Simon T. Bennett, John A. Todd, Joseph Nadeau, Rosemarie Grabs, Cynthia G. Goodyer, Saman Wickramasinghe, Eleanor Colle, Constantin Polychronakos, Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus Nature Genetics. ,vol. 15, pp. 289- 292 ,(1997) , 10.1038/NG0397-289