Fabrication and hemocompatibility of carboxy-chitosan stabilized magnetite nanoparticles
作者： Md. Abdur Rahman , Bungo Ochiai
DOI: 10.1007/S00542-017-3318-8
关键词:
摘要: This paper describes fabrication of a new hemocompatible, magnetic nanoparticles based on magnetite and naturally occurring chitosan, potentially applicable as biomaterials to nanobiomedicine. We fabricated carboxy-functionalized magnetite–chitosan (Fe3O4–CS–BTCDA) nanocomposite particles by simple two-stage protocol. Magnetite–chitosan (Fe3O4–CS) were first prepared via in situ chemical coprecipitation reactions using Fe2+ Fe3+ salts an alkaline aqueous solution CS. Fe3O4–CS then reacted with butanetetracarboxylic dianhydride (BTCDA) obtain the Fe3O4–CS–BTCDA dispersible under physiological conditions. The obtained are superparamagnetic. hemolytic activity is very low essential for practical bio-related applications.
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