A-Kinase Anchoring Proteins as the Basis for cAMP Signaling

摘要: Common challenges to any cell are the processing of extracellular stimuli it receives into intracellular signaling cascades that initiate a multitude diverse biological functions. However, many these act via common pathway, suggesting must somehow discriminate between different and respond accordingly. Subcellular targeting through association with adaptor scaffolding proteins has emerged as key mechanism by which cells maintain specificity. Compartmentation cAMP is maintained clustering enzymes in discrete units protein A-kinase anchoring (AKAP). In doing so, AKAPs provide molecular architecture for micordomains underlie spacial-temporal control signaling.