HIGH GENETIC SUSCEPTIBILITY TO ETHANOL WITHDRAWAL PREDICTS LOW ETHANOL CONSUMPTION

摘要: C57BL/6J (B6) inbred mice are well known to drink large amounts of alcohol (ethanol) voluntarily and have only modest ethanol-induced withdrawal under fixed dose conditions. In contrast, DBA/2J (D2) ``teetotallers'' exhibit severe ethanol withdrawal. Speculation that an inverse genetic relationship existed between these two traits was substantiated by meta-analysis existing data collected in multiple models, including panels standard recombinant strains, their crosses, selectively bred mouse lines. Despite methodological differences among laboratories measurement both preference drinking withdrawal, a nearly universal finding genotypes consuming 10% (calculated as g/kg/day) during two-bottle choice were genetically predisposed low scores independent studies after either acute or chronic treatment. Conversely, low-drinking had higher severity scores. The appears be strongest populations derived from B6 D2, where more (BXD RIs, B6D2F2s, BXD RI F1s, B6D2F2-derived lines) available for analysis. Gene mapping identified four chromosome regions [on Chromosomes (Chrs) 1, 2, 4, 15] genes might potentially influence traits. Among with greater diversity (for example, panel strains lines), the less pronounced. Thus, reduced susceptibility development high use may supported increased symptoms.