Studies on Human Pharmaceuticals in Jordanian Wastewater Samples

摘要: Eight pharmaceuticals, the anti-epileptic carbamazepine, two antibiotics sulfamethoxazole and erythromycin, five non-steroidal anti-inflammatory drugs ibuprofen, naproxen, diclofenac, ketorolac, ketoprofen were analyzed in influents effluents of wastewater treatment plants Jordan. After solid phase extraction at pH 4, analytes determined by LC-MS/MS using multiple reaction monitoring mode. For quantitation purposes, external calibration was applied first. Regression coefficients ≥0.995 indicated linearity concentration range 0.5–100 ng/μL. Finally, single-point standard addition to compensate matrix effects. The instrumental detection limits between 0.05 20 pg amount injected. method for spiked influent effluent samples 0.5 0.2 μg/L, respectively. Recovery rates ≥78%. Precision given as relative deviations within-day precision time-different intermediate ranged from 2 21 1 19%, In this study, maximum average concentrations found ibuprofen 5.7 μg/L 2.2 μg/L samples. other pharmaceuticals 0.7 5.2 0.2 1.3 μg/L, Ketorolac not detected.