Diagnosis of penicillin, amoxicillin, and cephalosporin allergy: reliability of examination assessed by skin testing and oral challenge.

摘要: The specificity of pediatrician-diagnosed allergy reactions to penicillin, amoxicillin, and oral cephalosporins, which was based on contemporaneous examination the patient, evaluated by an elective skin testing program. Children adolescents (n = 247) experiencing adverse reaction and/or cephalosporin sufficient lead recommendation avoid further use were enrolled. Skin with penicillin G, commercial benzylpenicilloyl phosphate, minor determinate mixture, ampicillin, cefazolin, cefuroxime, ceftriaxone performed according suspected drug followed challenge, repeat testing, prospective follow-up if no observed. Overall, 84 (34.0%) 247 patients had IgE-type or challenge. Twenty-seven (32%) 85 reactions, 53 (34%) 156 amoxicillin 13 (50%) 26 shown be IgE mediated. Positive tests observed in 20 non-IgE-type clinical including 15 only a pruritic polymorphous rash. No challenge severe after negative testing. One hundred sixty-three received multiple treatment courses beta-lactam antibiotics procedure three (1.8%) all mild. Physician-diagnosed allergic patient at time is more accurate than history alone but still overestimates rate possible true 66% patients. Elective protocols are necessary identify not risk.