Comparison of microbial communities in sequencing batch reactors (SBRs) exposed to trace erythromycin and erythromycin-H2O

摘要: Wastewater treatment plants (WWTPs) are major collection pools of antibiotics which low concentrations may induce antibiotic resistance in their microbial communities and pose threat to human health. However, information is still limited on the community alteration WWTPs upon exposure low-dose due absence negative control systems without input resistant bacteria genes. Here we report impact trace erythromycin (ERY) dehydrated (ERY-H2O) dynamics three long-term (1 year) running sequencing batch reactors (SBRs), R1 (ERY-H2O), R2 (ERY), R3. The PhyloChip microarray analysis showed that ERY-H2O ERY significantly altered based bacterial richness (e.g., 825 operational taxonomic units (OTUs) R1, 699 OTUs R2, 920 R3) population abundance (15 48 subfamilies with >80 % decrease respectively). have broad but distinct antimicrobial spectrums. For example, all phyla (i.e., Proteobacteria, Actinobacteria, Bacteroidetes, Chloroflexi) present SBRs were severely inhibited by ERY, Acidobacteria, Chlorobi, Firmicutes, Nitrospira OP10 only ERY. Very groups or through forming biofilms Zoogloea) synthesizing proteins Thauera, Candidatus Accumulibacter, Competibacter, Dechloromonas) SBRs. Inhibition was observed be main effect reactors. results would broaden our knowledge effects WWTPs.