Inflammatory aspects of sleep apnea and their cardiovascular consequences.

摘要: Obstructive sleep apnea (OSA) is a common medical condition that occurs in considerable percentage of the population. Substantial evidence shows patients with OSA have an increased incidence hypertension compared individuals without OSA, and risk factor for development hypertension. It established may be implicated stroke transient ischemic attacks. associated coronary heart disease, failure, cardiac arrhythmias. Pulmonary especially pre-existing pulmonary disease. Although exact cause links cardiovascular disease unknown, there group proinflammatory prothrombotic factors been identified as important atherosclerosis. daytime nocturnal sympathetic activity. Autonomic abnormalities seen include resting rate, decreased R-R interval variability, blood pressure variability. Both atherosclerosis are endothelial dysfunction, C-reactive protein, interleukin 6, fibrinogen, plasminogen activator inhibitor, reduced fibrinolytic has enhanced platelet activity aggregation. Leukocyte adhesion accumulation on cells both Clinicians should aware