Emerging role of cystic fibrosis transmembrane conductance regulator as an epigenetic regulator: linking environmental cues to microRNAs.

摘要: Summary Although microRNAs (miRNAs) have been recognized as one of the important epigenetic mechanisms that regulate gene expression in response to changes environment, links between environmental cues and miRNAs remain largely unknown. Localized cell membrane an anion channel, cystic fibrosis transmembrane conductance regulator (CFTR) has recently shown mediate signalling pathways leading activation miRNAs. This brief review summarizes related findings discusses emerging role CFTR regulator, possibly involved a wide spectrum physiological pathological processes.