Cyclooxygenases, Thromboxane, and Atherosclerosis Plaque Destabilization by Cyclooxygenase-2 Inhibition Combined With Thromboxane Receptor Antagonism

作者: Karine M Egan , Miao Wang , Margaret B Lucitt , Alicia M Zukas , Ellen Puré

DOI: 10.1161/01.CIR.0000153386.95356.78

关键词:

摘要: … Conclusions— TP antagonism is more effective than combined … with a TP antagonist, failed to modify disease progression but may undermine plaque stability when combined with the …

参考文章(51)
Serge Simonet, Jean-Jacques Descombes, Marie-Odile Vallez, Thierry Dubuffet, Gilbert Lavielle, Tony J. Verbeuren, S 18886, a New Thromboxane (TP)-Receptor Antagonist Is the Active Isomer of S 18204 in All Species, Except in the Guinea-Pig Advances in Experimental Medicine and Biology. ,vol. 433, pp. 173- 176 ,(1997) , 10.1007/978-1-4899-1810-9_35
Domenico Praticò, Tillmann Cyrus, Hongwei Li, Garret A. FitzGerald, Endogenous biosynthesis of thromboxane and prostacyclin in 2 distinct murine models of atherosclerosis. Blood. ,vol. 96, pp. 3823- 3826 ,(2000) , 10.1182/BLOOD.V96.12.3823
Takahiko Murata, Fumitaka Ushikubi, Toshiyuki Matsuoka, Masakazu Hirata, Atsushi Yamasaki, Yukihiko Sugimoto, Atsushi Ichikawa, Yoshiya Aze, Takashi Tanaka, Nobuaki Yoshida, Akinori Ueno, Sachiko Oh-ishi, Shuh Narumiya, Altered pain perception and inflammatory response in mice lacking prostacyclin receptor Nature. ,vol. 388, pp. 678- 682 ,(1997) , 10.1038/41780
John A. Lawson, Hongwei Li, Joshua Rokach, Mustafa Adiyaman, Seong-Woo Hwang, Subhash P. Khanapure, Garret A. FitzGerald, Identification of Two Major F2 Isoprostanes, 8,12-Iso- and 5-epi-8,12-Iso-isoprostane F2α-VI, in Human Urine Journal of Biological Chemistry. ,vol. 273, pp. 29295- 29301 ,(1998) , 10.1074/JBC.273.45.29295
Christopher S. R. Baker, Roger J. C. Hall, Thomas J. Evans, Ariela Pomerance, Jacques Maclouf, Christophe Creminon, Magdi H. Yacoub, Julia M. Polak, Cyclooxygenase-2 Is Widely Expressed in Atherosclerotic Lesions Affecting Native and Transplanted Human Coronary Arteries and Colocalizes With Inducible Nitric Oxide Synthase and Nitrotyrosine Particularly in Macrophages Arteriosclerosis, Thrombosis, and Vascular Biology. ,vol. 19, pp. 646- 655 ,(1999) , 10.1161/01.ATV.19.3.646
Mette Olesen, Elizabeth Kwong, Arguello Meztli, Frederic Kontny, Ingebjörg Seljeflot, Harald Arnesen, Line Lyngdorf, Erling Falk, No effect of cyclooxygenase inhibition on plaque size in atherosclerosis-prone mice. Scandinavian Cardiovascular Journal. ,vol. 36, pp. 362- 367 ,(2002) , 10.1080/140174302762659094
Jeng-Jiann Chiu, Pei-Ling Lee, Cheng-Nan Chen, Chih-I Lee, Shun-Fu Chang, Li-Jing Chen, Sheng-Chieh Lien, Ya-Chen Ko, Shunichi Usami, Shu Chien, None, Shear Stress Increases ICAM-1 and Decreases VCAM-1 and E-selectin Expressions Induced by Tumor Necrosis Factor-α in Endothelial Cells Arteriosclerosis, Thrombosis, and Vascular Biology. ,vol. 24, pp. 73- 79 ,(2004) , 10.1161/01.ATV.0000106321.63667.24
Joseph E. Dinchuk, Bruce D. Car, Richard J. Focht, Jennifer J. Johnston, Bruce D. Jaffee, Maryanne B. Covington, Nancy R. Contel, Vicki M. Eng, Robert J. Collins, Philip M. Czerniak, Stewart A. Gorry, James M. Trzaskos, Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II. Nature. ,vol. 378, pp. 406- 409 ,(1995) , 10.1038/378406A0