A Primate APOL1 Variant That Kills Trypanosoma brucei gambiense

摘要: Humans are protected against infection from most African trypanosomes by lipoprotein complexes present in serum that contain the trypanolytic pore-forming protein, Apolipoprotein L1 (APOL1). The human-infective trypanosomes, Trypanosoma brucei rhodesiense East Africa and T. b. gambiense West have separately evolved mechanisms allow them to resist APOL1-mediated lysis cause human trypanosomiasis, or sleeping sickness, man. Recently, APOL1 variants were identified a subset of Old World monkeys, able lyse rhodesiense, virtue C-terminal polymorphisms protein hinder parasite’s resistance mechanism. Such been proposed as candidates for developing therapeutic alternatives unsatisfactory anti-trypanosomal drugs currently use. Here we demonstrate vitro lytic ability purified recombinant an ortholog Guinea baboon (Papio papio), which is examples all sub-species including group 1 parasites, common agent trypanosomiasis. identification variant with both could be candidate universal APOL1-based strategies, targeted pathogenic trypanosomes.