Managing elderly people's osteoporosis. Why? Who? How?

作者: Juby A

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摘要: OBJECTIVE: To guide family physicians through assessment of why treating elderly people's osteoporosis is necessary, who to treat, and how treat in a practical way. QUALITY OF EVIDENCE: Evidence the efficacy treatment for shown by reduced probability fracture. This can be ascertained direct evaluation bisphosphonates, calcium, calcitonin, or indirectly ascertaining benefit bone mineral density hormone replacement therapy (HRT) exercise. MAIN MESSAGE: Unless medically contraindicated, all people should take supplementary vitamin D (800 IU/d) calcium (1500 mg/d). Those with risk factors (e.g., smoking, thinness, previous fracture when older than 50 years, first-degree relatives steroid use) have measurement. meeting World Health Organization criteria also treated HRT bisphosphonates possibly selective estrogen receptor modulators. CONCLUSIONS: Good evidence indicates that adequate prevent fractures thus reduce associated morbidity mortality among vulnerable people. Because prevalence osteoporosis, onus falls on front-line managers.

参考文章(39)
Thomas Mätzsch, David Bergqvist, Ulla Hedner, Bo Nilsson, Per Østergaar, Effects of low molecular weight heparin and unfragmented heparin on induction of osteoporosis in rats. Thrombosis and Haemostasis. ,vol. 63, pp. 505- 509 ,(1990) , 10.1055/S-0038-1645074
G. P. Lyritis, N. Tsakalakos, B. Magiasis, T. Karachalios, A. Yiatzides, M. Tsekoura, Analgesic effect of salmon calcitonin in osteoporotic vertebral fractures: a double-blind placebo-controlled clinical study. Calcified Tissue International. ,vol. 49, pp. 369- 372 ,(1991) , 10.1007/BF02555844
BRUCE ETTINGER, Long-Term Estrogen Replacement Therapy Prevents Bone Loss and Fractures Annals of Internal Medicine. ,vol. 102, pp. 319- 324 ,(1985) , 10.7326/0003-4819-102-3-319
K. Overgaard, M. A. Hansen, S. B. Jensen, C. Christiansen, Effect of salcatonin given intranasally on bone mass and fracture rates in established osteoporosis: a dose-response study. BMJ. ,vol. 305, pp. 556- 561 ,(1992) , 10.1136/BMJ.305.6853.556
S.R. Cummings, W. Browner, S.R. Cummings, D.M. Black, M.C. Nevitt, W. Browner, H.K. Genant, J. Cauley, K. Ensrud, J. Scott, T.M. Vogt, Bone density at various sites for prediction of hip fractures The Lancet. ,vol. 341, pp. 72- 75 ,(1993) , 10.1016/0140-6736(93)92555-8
Pierre D. Delmas, Nina H. Bjarnason, Bruce H. Mitlak, Anne-Catherine Ravoux, Aarti S. Shah, William J. Huster, Michael Draper, Claus Christiansen, Effects of Raloxifene on Bone Mineral Density, Serum Cholesterol Concentrations, and Uterine Endometrium in Postmenopausal Women New England Journal of Medicine. ,vol. 337, pp. 1641- 1647 ,(1997) , 10.1056/NEJM199712043372301
Steven L. Wolf, Nancy G. Kutner, Robert C. Green, Elizabeth McNeely, The Atlanta FICSIT Study: Two Exercise Interventions to Reduce Frailty in Elders Journal of the American Geriatrics Society. ,vol. 41, pp. 329- 332 ,(1993) , 10.1111/J.1532-5415.1993.TB06713.X
Jacques Massé, Effect of subclinical and overt hypothyroidism on the plasma lipid profile. The American Journal of Medicine. ,vol. 95, pp. 553- ,(1993) , 10.1016/0002-9343(93)90347-R
Tjeerd van Staa, Lucien Abenhaim, Cyrus Cooper, Upper Gastrointestinal Adverse Events and Cyclical Etidronate The American Journal of Medicine. ,vol. 103, pp. 462- 467 ,(1997) , 10.1016/S0002-9343(97)00242-8