Functional role of exogenous administration of substance P in chronic constriction injury model of neuropathic pain in gerbils.

摘要: Abstract Substance P (SP) acts as a transmitter of nociception in both the peripheral and central nervous system. Because NK-1 receptors gerbils are comparable to those humans, gerbil models could be used study role SP neuropathic pain. A modification rat chronic constriction injury (CCI) model pain was produced male by placing four loose chromic catgut ligatures around sciatic nerve. This procedure clearly resulted mechanical hypersensitivity. Intraplantar injections selective receptor agonist, [Sar 9 -Met(O 2 ) 11 ]-substance (Sar-SP), paw ipsilateral nerve intrathecal administration these peptides paw-lifting behavior CCI thermoneutral conditions. In sham-operated nonoperated controls, no such effects were observed. Systemic antagonist R116301 attenuated Sar-SP-induced indicating effects. injection highest dose (200 ng) contralateral lifting injury, indicative for spinal mechanisms especially since front or even intracardially did not have any effect at all. The SP-induced responses antagonized NMDA MK801. These results indicate that reveal an increased reactivity model. sensitivity seems involve mechanisms.