Traditional serrated adenoma-like lesions in patients with inflammatory bowel disease

摘要: Summary Patients with inflammatory bowel disease (IBD) have an increased risk of colorectal carcinoma. The significance serrated lesions resembling traditional adenoma (TSA) in IBD patients is unclear. In this retrospective study, we analyzed 52 TSA-like arising 30 and diagnosed colectomy or endoscopic specimens. 27 presented predominantly as ill-defined areas granular appearance, a median size 15 mm, located throughout the large associated synchronous advanced 58%. Low-grade dysplasia was present 56%, high-grade 37%, TSA-type cytology 7%. Increased Ki-67 immunostaining abnormal p53 expression were identified 96% 48%, respectively; 74% had KRAS mutation, 4% BRAF mutation. Endoscopically resectable all discrete polypoid lesions, smaller (median 9 mm), distal bowel, adjacent precursor polyp 24%, metachronous 6%. Most (92%) show cytology. overexpression 4%, mutation 41%, 32%. None demonstrated loss MLH1 SATB2 by immunohistochemistry. On follow-up, 4 carcinoma adenomatous IBD-associated dysplasia. showing only developed lesion. Our findings suggest that some essentially from colectomy, may represent form neoplasia.