Thermal and Photolytic Decomposition of Methotrexate in Aqueous Solutions

摘要: The chemical kinetics of thermal and photolytic degradation methotrexate in aqueous solutions were studied. At above pH 7 85 degrees, hydrolyzed to yield mainly N10-Methylpteroylglutamic acid. hydrolysis rate followed first-order with respect concentration increases rapidly 9. When kept under laboratory fluorescent light, the major products 2,4-diamino-6-pteridinecarbaldehyde, 2,4-diamino-6-pteridinecarboxylic acid, p-aminobenzoylglutamic reaction zero-order was catalyzed by bicarbonate ion. Evidence is presented for a proposed sequential cleavage free radical mechanism photolysis. Commercial parenteral found be quite stable as marked when stored original vial at room temperature.