Addition of high-risk HPV testing improves the current guidelines on follow-up after treatment for cervical intraepithelial neoplasia

摘要: We assessed a possible role for high-risk human papillomavirus (HPV) testing in the policy after treatment cervical intraepithelial neoplasia (CIN) 2 or 3 (moderate to severe dysplasia). According Dutch guidelines follow-up consists of cytology at 6, 12 and 24 months. Colposcopy is only performed case abnormal cytology. In this observational study 184 women treated CIN were prospectively monitored by HPV 3, 9, months treatment. Post-treatment 2/3 was present 29 (15.8%). A positive test 6 more predictive post-treatment than (sensitivity 90% 62% respectively, with similar specificity). At negative value negative, normal smear, 99%. Largely overlapping, partly different groups identified Based on these results we advocate include monitoring initially 2/3. cytology, colposcopy indicated. All should be tested referred population-based cancer screening programme when tests are both visits.