Patient values and preferences regarding VTE disease: a systematic review to inform American Society of Hematology guidelines.

摘要: Values and preferences relate to the importance that patients place on health outcomes (eg, bleeding, having a deep venous thrombosis) are essential when weighing benefits harms in guideline recommendations. To inform American Society of Hematology guidelines for management thromboembolism (VTE) disease, we conducted systematic review patients' values related VTE. We searched Medline, Embase, Cochrane Central Register Controlled Trials, PsycINFO, Cumulative Index Nursing Allied Health Literature from inception April 2018 (PROSPERO-CRD42018094003). included quantitative qualitative studies. followed Grading Recommendations Assessment, Development Evaluation (GRADE) guidance rating certainty presenting findings research about relative grounded theory approach thematic synthesis. identified 14 studies (2465 participants) describing VTE-related states widely diverse population patients, showing overall small important impact lives (certainty evidence low moderate). Additionally, 34 (6424 15 (570 revealed put higher value VTE risk reduction than potential treatment Studies also suggested clear preference oral medication over subcutaneous (moderate certainty). The observed variability state may be result differences approaches used elicit them diversity populations rather true values. This finding highlights necessity explore induced by different ascertain