Fungal Recognition by TLR2 and Dectin-1.

作者: Helen S. Goodridge , David M. Underhill

DOI: 10.1007/978-3-540-72167-3_5

关键词:

摘要: The innate immune system utilizes multiple receptors to recognize fungal pathogens, and the net inflammatory response is controlled by interactions between these receptors. Many fungi are recognized, at least in part, Toll-like receptor 2 (TLR2) Dectin-1. Examination of roles play together on their own a useful model for understanding interplay This review focuses role(s) TLR2 Dectin-1 triggering responses, transcription factor activation, phagocytosis, reactive oxygen production fungi.

参考文章(79)
Jiří Manych, Aspergillosis Infectious Disease Clinics of North America. ,vol. 16, pp. 875- 894 ,(2002) , 10.1016/S0891-5520(02)00035-1
Ruslan Medzhitov, Paula Preston-Hurlburt, Charles A. Janeway, A human homologue of the Drosophila Toll protein signals activation of adaptive immunity Nature. ,vol. 388, pp. 394- 397 ,(1997) , 10.1038/41131
Sigrid E. M. Heinsbroek, Philip R. Taylor, Marcela Rosas, Janet A. Willment, David L. Williams, Siamon Gordon, Gordon D. Brown, Expression of Functionally Different Dectin-1 Isoforms by Murine Macrophages Journal of Immunology. ,vol. 176, pp. 5513- 5518 ,(2006) , 10.4049/JIMMUNOL.176.9.5513
Silvia Bellocchio, Claudia Montagnoli, Silvia Bozza, Roberta Gaziano, Giordano Rossi, Salamatu S. Mambula, Annunciata Vecchi, Alberto Mantovani, Stuart M. Levitz, Luigina Romani, The Contribution of the Toll-Like/IL-1 Receptor Superfamily to Innate and Adaptive Immunity to Fungal Pathogens In Vivo Journal of Immunology. ,vol. 172, pp. 3059- 3069 ,(2004) , 10.4049/JIMMUNOL.172.5.3059
Geoffrey M. Gersuk, David M. Underhill, Liqun Zhu, Kieren A. Marr, Dectin-1 and TLRs Permit Macrophages to Distinguish between Different Aspergillus fumigatus Cellular States Journal of Immunology. ,vol. 176, pp. 3717- 3724 ,(2006) , 10.4049/JIMMUNOL.176.6.3717
Helen S. Goodridge, Randi M. Simmons, David M. Underhill, Dectin-1 Stimulation by Candida albicans Yeast or Zymosan Triggers NFAT Activation in Macrophages and Dendritic Cells Journal of Immunology. ,vol. 178, pp. 3107- 3115 ,(2007) , 10.4049/JIMMUNOL.178.5.3107
S R Lundy, W M Mackin, K R Gans, R L Dowling, J S Kerr, T M Stevens, Kinetics of phospholipase A2, arachidonic acid, and eicosanoid appearance in mouse zymosan peritonitis. Journal of Immunology. ,vol. 144, pp. 2671- 2677 ,(1990)
David M. Underhill, Adrian Ozinsky, Adeline M. Hajjar, Anne Stevens, Christopher B. Wilson, Michael Bassetti, Alan Aderem, The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens Nature. ,vol. 401, pp. 811- 815 ,(1999) , 10.1038/44605
Mihai G. Netea, Roger Sutmuller, Corinna Hermann, Chantal A. A. Van der Graaf, Jos W. M. Van der Meer, Johan H. van Krieken, Thomas Hartung, Gosse Adema, Bart Jan Kullberg, Toll-Like Receptor 2 Suppresses Immunity againstCandida albicansthrough Induction of IL-10 and Regulatory T Cells The Journal of Immunology. ,vol. 172, pp. 3712- 3718 ,(2004) , 10.4049/JIMMUNOL.172.6.3712
M.G. Netea, J.W.M. Van der Meer, B-J. Kullberg, Role of the dual interaction of fungal pathogens with pattern recognition receptors in the activation and modulation of host defence. Clinical Microbiology and Infection. ,vol. 12, pp. 404- 409 ,(2006) , 10.1111/J.1469-0691.2006.01388.X