Neuromyelitis Optica: An Antibody-Mediated Disorder of the Central Nervous System
作者： Jiwon Oh , Michael Levy
DOI: 10.1155/2012/460825
关键词:
摘要: Neuromyelitis optica (NMO) is a recurrent inflammatory disease that preferentially targets the optic nerves and spinal cord leading to blindness paralysis. The hallmarks of NMO include bilateral neuritis longitudinally extensive transverse myelitis. Woman African Americans are overrepresented in US patient population. associated with NMO-IgG biomarker, which aquaporin-4 water channel on astrocytes. humoral pathology lesions IgG IgM deposits infiltration by granulocytes suggesting may be involved pathogenesis disease. This review recent literature covers clinical features, epidemiology, radiology includes discussion important basic science research work field.
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