Comparative Pharmacokinetics of Antifungal Drugs In Domestic Turkeys, Red-Tailed Hawks, Broad-Winged Hawks, and Great-Horned Owls

摘要: The present research was to test in vitro activity of thiabendazole, 5-fluorocytosine, and amphotericin B against 11 isolates Aspergillus fumigatus from avian species. Additionally, the plasma concentrations these drugs were determined four species given a range dosages by oral, intravenous, intratracheal routes. Thiabendazole inhibited most at between 25 50 micrograms/ml; however, there no detectable inhibitory any doses. arithmetic mean minimum concentration for 5-fluorocytosine 2.73 micrograms/ml. Inhibitory found 2 6 hours post-administration all when oral doses 30 or 60 mg/kg as single dose three divided day totaling 120 mg/kg. No 24 post-administration. only birds receiving 1.5 2-hour intervals. A. 0.81