Radiographic patterns of symptomatic radiation pneumonitis in lung cancer patients: Imaging predictors for clinical severity and outcome.

摘要: Abstract Objective Investigate the spectrum of radiographic patterns radiation pneumonitis (RP) in lung cancer patients and identify imaging markers for high-grade RP RP-related death. Methods Eighty-two with treated conventional chest radiotherapy who had symptomatic were identified from oncology database. The features studied association (Grade ≥3) death 5). Results was Grade 2 60 (73%), 3 15 (18%), 5 7 (9%). Lower performance status (p = 0.04), squamous cell histology (p = 0.03), FEV1 ≤ 2 (p = 0.009) associated pneumonitis. Older age (p = 0.03) CT findings included ground-glass reticular opacities all patients, traction bronchiectasis 77 (94%) consolidation 74 (90%). most common pattern cryptogenic organizing pneumonia (COP) (n = 54), followed by acute interstitial (AIP)/acute respiratory distress syndrome (ARDS) (n = 10). Higher extent involvement, diffuse distribution, AIP/ARDS a significant factor (OR:12.62, p = 0.01) multivariable analyses adjusting clinical variables. Conclusion COP patients. significantly deaths, an independent marker RP. recognition can help to effectively contribute patient management.