Improved Biomechanical and Biological Outcomes in the MRL/MpJ Murine Strain Following a Full-Length Patellar Tendon Injury

摘要: Musculoskeletal injuries greatly affect the U.S. population and current clinical approaches fail to restore long-term native tissue structure function. Tissue engineering is a strategy advocated improve tendon healing; however, field still needs establish biological benchmarks for assessing effectiveness of tissue-engineered structures. Investigating superior healing models, such as MRL/MpJ, offers opportunity first characterize successful then apply experimental findings therapies. This study seeks evaluate MRL/MpJ's response following central patellar injury compared wildtype. Gene expression histology were assessed at 3, 7, 14 days mechanical properties measured 2, 5, 8 weeks. Native not different between strains. Following injury, MRL/MpJ displayed increased 5 weeks; early tenogenic patterns Furthermore, cyclin-dependent kinase inhibitor, p21, was strains, suggesting an alternative mechanism may be driving response. Future studies will investigate collagen alignment repair complete transcriptome identify mechanisms © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:1693–1703, 2015.