Experimental evaluation of potential anticancer agents VIII. Effects of certain nitrosoureas on intracerebral L1210 leukemia.

摘要: Summary In quantitative therapeutic studies 1,3-bis(2-chloroethyl)-1-nitrosourea (NSC-409962) and 1-(2-chloroethyl)-1-nitrosourea (NSC-47547) have been shown to marked activity against intraperitoneal (I.P.) L1210 leukemia when administered by the I.P., subcutaneous, or oral route. This class of compounds is first be observed possess an encouraging degree intracerebrally inoculated leukemia. Of “active” derivatives 1-methyl-1-nitrosourea studied date, only those which a higher lipoid solubility are essentially not ionized capacity affect intracerebral (I.C.) Evidence has obtained suggests that mechanism action (at biochemical level) may similar certain well known alkylating agents. Experiments with bilateral implants agent-sensitive -resistant plasmacytoma in hamsters showed latter tumor cross-resistant these compounds.