Using natural STOP growth signals to prevent excessive axial elongation and the development of myopia.

摘要: Myopia is emerging as a major public health issue due to its increasing prevalence and long-term pathological outcomes. Prevention must focus on limiting excessive axial elongation which the cause of both myopic refractive error The appears be environmental changes involving near work, rather than genetic failure emmetropisation. Attempts control progression myopia optically have been unsuccessful; only available preventive regime involves use atropine eye drops. This has short-term side effects, since site mechanism action muscarinic antagonists are unclear, there concerns about safety. Recent studies natural STOP growth signals suggest that they evoked by relatively brief periods imposed defocus, can overcome strong pressures towards increased elongation. While successfully used in chickens prevent elongation, similar generated mammals non-human primates. Further may define conditions under this approach could development humans.