Heteropolymer-mediated clearance of immune complexes via erythrocyte CR1: mechanisms and applications.

摘要: Summary: Opsonization of particulate pathogens by antibodies and complement can lead to their binding the receptor (CR1), specific for C3b, on primate erythrocytes (E). This process immune adherence may play a role in immunologic defense immobilizing bacteria viruses, thus preventing them from leaving bloodstream invade susceptible tissue organs. Immune C3b-opsonized complexed E also facilitate transfer to, destruction by, fixed macrophages. We have used mAbs CR1 crosslinked with pathogen generate heteropolymers (HP) which bind wide range substrates erythrocytes. Both prototype bonafide bound via HP are handled circulation non-human primates manner appears be virtually identical mechanism cleared. In this focused phagocytosis, Fc receptors phagocytic cell engage E-bound complex, is removed proteolysis, entire complex internalized while sparing E. It possible use target therapeutic applications.