作者: Stephen J. Tuft , Lalitha C. Moodaley , Walter M. Gregory , Charles R. Davison , Roger J. Buckley
DOI: 10.1016/S0161-6420(94)31313-3
关键词:
摘要: Conclusions: The progression of keratoconus to a stage where penetrating keratoplasty (PK) is required for visual rehabilitation has considerable implications affected patients. To assist with counselling, the authors have attempted identify which factors measurable early in course disease may indicate likelihood subsequent surgery. Methods: reviewed records all patients who attended single center over 7-year period contact lens management their keratoconus. influence clinical variables on time taken worst eye progress PK was evaluated by actuarial methods and multivariate analysis. Results: Included study were 2723 mean follow-up unoperated eyes from first visit 4.5 years (range, 3 months 28 years). Data available analysis 2363 At end period, 757 (21.6% patients) had been grafted. number progressing independently related both maximum minimum keratometry, corneal cylinder more than 1.9 mm, Snellen acuity, racial group ( P = 0.0006). Sex, laterality, systemic atopic disease, maternal or paternal age at birth, joint hypermobility, family history not statistically outcome. Progression one increased risk contralateral Several can be measured presentation that probability PK.