The reaction of oximes with 4-phenyl-1,2,4-triazoline-3,5-dione to produce nitric oxide – Model compounds for nitric oxide synthase
作者： Anton W. Jensen , Daryl Flotka , Tianzuo Xu , Alexis E. Pullizzi , Wendell L. Dilling
DOI: 10.1016/J.TETLET.2018.04.064
关键词:
摘要: Abstract Certain oximes form nitric oxide upon reaction with 4-phenyl-1,2,4-triazole-3,5-dione (PTAD). The appear to undergo an Alder-ene the PTAD enophile a nitroso intermediate capable of dimerization and/or formation. Upon exposure oxygen, compounds eventually ketones. This may serve as model for study synthase (NOS), enzyme responsible physiological production oxide. NOS is known produce oxime which reacts oxygen and citrulline.
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