The impact of multiple recurrences in disease-free survival of breast cancer: an extended Cox model.

摘要: Aims and background. Identifying the risk factors of recurrence breast cancer is important for both physician patient. Analysis first may lead to an inaccurate evaluation factor's effects because it does not completely reflect history disease result in loss valuable information. The present study aimed determine that influence estimate disease-free survival, adjusting multiple metastases patients. Methods design. Patients were selected from a longitudinal carried out at Fayazabakhsh Hospital Tehran, Iran. Women who diagnosed with underwent either modified radical mastectomy or breast-conserving surgery between January 2006 April 2008 recruited take part study. Breast was defined as occurrence tumor contralateral breast, local-regional relapse, distant metastasis other organs. Using extended Cox model, effect age, size, estrogen receptors, HER2, progesterone receptors well lymph node ratio analyzed. Results. Over 5833 person-month follow-up, 25 133 patients (18.8%) had died 108 (81.2%) still alive, 9 them metastasis. Thirty-four (25.6%) experienced their recurrence. A total 11 second mean time 19.93 months, gap two 7.15 months. Risk experiencing death third fifth year after approximately 22% 28%, respectively. Fitting recurrent regression shows high ratio, histologic grade, large size HER2-positive tumors are prognostic shorter survival. Conclusions. Our novel approach might be helpful clinical practice predict adapted used malignancies well.