Anti‐inflammatory action of dapsone: inhibition of neutrophil adherence is associated with inhibition of chemoattractant‐induced signal transduction

摘要: Dapsone has clinical utility as an anti-inflammatory agent but the mechanism of this action remains unknown. We have previously reported that dapsone inhibits beta2 integrin (CD11b/CD18)-mediated adherence human neutrophils in vitro and now describe studies designed to discover how dapsone-mediated inhibition neutrophil function occurs. Results indicate interferes with activation or G-protein (Gi type) initiates signal transduction cascade common chemotactic stimuli. They also show suppression pathway generation second messengers essential molecules, well respiratory secretory functions exposed chemoattractants. propose chemoattractant-induced by suppresses recruitment local production toxic products affected skin dermatitis herpetiformis other neutrophilic dermatoses.