Low molecular mass proteins as markers for renal function and dialysis efficiency

摘要: Kidney disease is a growing problem in the whole world. It important to find these patients an early state of because then they can be treated and dialysis treatment avoided. To measure glomerular filtration rate (GFR) invasive technigue used. In this thesis equation estimate GFR (eGFR) by drawing blood sample concentration cystatin C presented. This first one working both for adults children. establish at all laboratories, primary secondary reference preparations were developed. The preparation will used international calibrator, which diagnostic companies uniform value C. Cystatin has been proposed marker inflammation. our study patients, without any prior inflammation, who undergo elective surgery, was unaltered while increase CRP seen. result shows that not Three different types treatments (haemodialysis, haemofiltration, haemodiafiltration) tested their capacity remove low molecular mass proteins (LMMP) thus potential with kidney failure. LMMP have uraemic toxins must therefore removed from circulation. showed C, β2-microglobulin β-trace protein as markers efficiency haemofiltration (HF) haemodiafiltration (HDF). elimination pattern differs between HDF HF free might useful evaluation convective therapies. (Less)