Relationship between surface concentration of L-leucine and bulk powder properties in spray dried formulations.
作者： Sharad Mangal , Felix Meiser , Geoffrey Tan , Thomas Gengenbach , John Denman
DOI: 10.1016/J.EJPB.2015.04.035
关键词:
摘要: Abstract The amino acid l -leucine has been demonstrated to act as a lubricant and improve the dispersibility of otherwise cohesive fine particles. It was hypothesized that optimum surface concentration is necessary achieve optimal bulk powder properties. Polyvinylpyrrolidone spray dried with different change in composition formulations determined using X-ray photoelectron spectroscopy (XPS) time flight-secondary ion mass spectrometry (ToF-SIMS). were also subjected diffraction analysis order understand relationship between solid-state properties -leucine. In addition, morphology, energy cohesion assessed relation increased higher feed concentrations plateaued at about 10% Higher resulted formation larger crystals not much crystal size noted above A morphology particles from spherical increasingly corrugated observed increasing concentration. Specific collapsed/folded over only seen or suggesting particle process. reduced approached minimum Thus, governs results
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