Vancomycin-modified Fe 3 O 4 @SiO 2 @Ag microflowers as effective antimicrobial agents

摘要: Nanomaterials combined with antibiotics exhibit synergistic effects and have gained increasing interest as promising antimicrobial agents. In this study, vancomycin-modified magnetic-based silver microflowers (Van/Fe3O4@SiO2@Ag microflowers) were rationally designed prepared to achieve strong bactericidal ability, a wide spectrum, good recyclability. High-performance Fe3O4@SiO2@Ag served multifunction-supporting matrix exhibited sufficient magnetic response property due their 200 nm Fe3O4 core. The also possessed highly branched flower-like Ag shell that provided large surface area for effective ion release bacterial contact. modified-vancomycin layer was effectively bound the cell wall of bacteria increase permeability membrane facilitate entry ions into bacterium, resulting in death. As such, fabricated Van/Fe3O4@SiO2@Ag predicted be an environment-friendly antibacterial agent. This hypothesis verified through sterilization Gram-negative Escherichia coli Gram-positive methicillin-resistant Staphylococcus aureus, minimum inhibitory concentrations 10 20 μg mL-1, respectively. showed enhanced effect compared bare free-form vancomycin, confirming combination two components. Moreover, maintained at more than 90% after five cycling assays, indicating high stability product. These findings reveal applications fields.