Early-Onset Bipolar Disorder and Treatment Delay Are Risk Factors for Poor Outcome in Adulthood
作者： Robert M. Post , Gabriele S. Leverich , Ralph W. Kupka , Paul E. Keck , Susan L. McElroy
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摘要: Objective We examined the influence of age at onset illness and delay in time to first treatment on morbidity adulthood. Method 529 adult outpatients with a mean 42 years, who entered our research network from 1996 through 2001 were diagnosed bipolar disorder according DSM-IV criteria, rated prospectively daily basis National Institute Mental Health-Life Chart during naturalistic for up 4 years. Results Fifty percent patients had childhood ( Conclusions These data converge other evidence that is common often associated extraordinarily long delays pharmacologic treatment. Both persistently more adverse course adults. should help foster efforts ensure earlier effective children adolescents. It hoped appropriate early intervention would result benign better prognosis
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