Traditional and new antipsychotic drugs differentially alter neurotransmission markers in basal ganglia-thalamocortical neural pathways.

摘要: The effects of three chronically administered antipsychotic drugs on selected neurochemical markers dopaminergic and GABAergic transmission were compared within the cerebral regions making up basal ganglia-thalamocortical parallel processing neuronal pathways. All reduce psychosis in humans, whereas only haloperidol, but not olanzapine or sertindole, induce purposeless oral chewing movements (CMs) rats cause high rates parkinsonism tardive dyskinesia humans. Male Sprague Dawley treated with delivered drinking water for 6 months at doses which produce drug plasma levels rat human therapeutic range. Results show expected dopamine D2 receptor upregulation striatum predominantly although mild was apparent after olanzapine. GAD67 mRNA increased decreased globus pallidus by haloperidol In substantia nigra pars reticulata (SNR), both sertindole failed to GABAA D1 downregulation, did both, confirming a previous report. thalamus, all GAD expression reticular nucleus, binding mediodorsal actions consistent reduction nigrothalamic, GABA-mediated neural transmission. These results are idea that two new antipsychotics tested have regionally restricted ganglia nuclei common action increasing nucleus thalamus (RtN). Haloperidol, contrast, has broad potent ganglia, causing changes SNR while also altering RtN, potentially reflective its dyskinetic actions. Synapse 39:152–160, 2001. © 2001 Wiley-Liss, Inc.