Specific bradycardic agents, a new therapeutic modality for anesthesiology: hemodynamic effects of UL-FS 49 and propranolol in conscious and isoflurane-anesthetized dogs

摘要: A “specific bradycardic agent” has direct negative chronotropic actions without producing other systemic or coronary hemodynamic alterations. UL-FS 49, a recently synthesized structural analog of verapamil classical slow channel calcium blocking activity, is proposed as such an agent. The purpose this investigation was to characterize the and electrocardiographic 49 (0.25, 0.50, 1.0 mg/kg) compare its effects with those propranolol in conscious isoflurane-anesthetized (with neuro-muscular blockade by pancuronium) chronically instrumented dogs. In six groups, comprising 52 experiments, found be more efficacious than reducing heart rate, although agent did not block response isoproterenol. produced 45–50% reductions rate dogs isoflurane-induced tachycardia compared 15 30% following propranolol. Furthermore, few he modynamic alterations were indicating remarkable specificity drug for rate. may useful clinically during perioperative period. Such especially advantageous patients documented suspected ischemic disease, who cannot tolerate side beta adrenergic blockade, well requiring greater reduction can obtained receptor antagonists.