AQUAPORIN-2 AND -3: Representatives of Two Subgroups of the Aquaporin Family Colocalized in the Kidney Collecting Duct

摘要: Since the molecular identification of first aquaporin in 1992, number proteins known to belong this family has been rapidly increasing. These members may be separated into two subgroups based on gene structure, sequence homology, and function. Regulation water permeability collecting ducts kidney is essential for urinary concentration. Aquaporin-2 -3, which are representative these subgroups, colocalized ducts. Understanding will elucidate differences between aquaporin-2 -3. a vasopressin-regulated channel located apical membrane, aquaporin-3 constitutive basolateral membrane. In contrast aquaporin-3, appears less well regulated, many studies have now identified multiple regulational mechanisms at gene, protein, cell levels aquaporin-2, thus reflecting its physiological importance. Evidence participation pathophysiology water-balance disorders accumulating.