Novel pyrene containing monomeric and dimeric supramolecular AIEE active nano-probes utilized in selective "off-on" trivalent metal and highly acidic pH sensing with live cell applications
作者： Muthaiah Shellaiah , Turibius Simon , Venkatesan Srinivasadesikan , Chein-Ming Lin , Kien Wen Sun
DOI: 10.1039/C5TC03738G
关键词:
摘要: Two novel pyrene containing monomeric and dimeric Schiff base derivatives PCS1 PCS2 have been synthesized via one-pot reaction their nano-J-type aggregation induced emission enhancement (AIEE) was well demonstrated using UV-Vis/PL, transmission electron microscopy (TEM), dynamic light scattering (DLS), time resolved photoluminescence (TRPL), live cell imaging studies. In contrast to PCS2, in CH3CN exhibits fluorescence “off–on” sensor selectivity towards transition trivalent metal ions (Fe3+, Cr3+ Al3+) among other metals, PET inhibition with excimer PCS1–PCS1* formation. The 2 : 1 stoichiometry of PCS1⋯M3+ (M = Fe/Cr/Al) complexes calculated from Job's plots based on PL titrations. addition, the binding sites were recognised 1H NMR titrations supported by ESI(+ve) mass FTIR analysis. Additionally, reversibilities observed consequent addition M3+ PMDTA, respectively. Furthermore, detection limits (LODs) association constant (Ka) values standard deviation linear fittings. Likewise, quantum yield (Φ) measurements, TEM analysis, determination effect pH, density functional theory (DFT) (TRPL) studies performed for complexes. More importantly, confocal Raw264.7 cells showed that could be used as an effective fluorescent probe detecting Cr3+, living cells. Impressively, both sensing at highly acidic pH (1–3) applications.
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