The Mechanosensitivity of Cells in Joint Tissues: Role in the Pathogenesis of Joint Diseases

摘要: Joint tissues, including cartilage, bone, meniscus, tendon, ligament and synovial membrane, are exposed to high mechanical stimulation. The response of these tissues strains is a key factor the OA onset progression. Any little failure in this function may lead cell phenotype alteration tissue damages. While responses cartilage well known, very few data available on effects other articular tissues. Mechanical loading plays dual role homeostasis joint tissues: when applied at moderate physiological range, stimuli beneficial good health whereas excessive initiate abnormal remodeling structural changes. Appropriate load could play an important This raises question played by exercises prevention treatment OA. paper narrative review based selected recent literature field.