Human papillomavirus in squamous cell carcinoma of esophagus in a high-risk population
作者： Mohammad Farhadi , Zahra Tahmasebi , Shahin Merat , Farin Kamangar , Dariush Nasrollahzadeh
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摘要: Introduction and Aims: The role of human papillomavirus (HPV) in the etiology esophageal squamous cell carcinoma (ESCC) is not clear. Previous studies have found highly variable (from 0% to 67%) prevalence HPV ESCC tumor. However, tumor seems be higher areas with high incidence , such as China South Africa. Iran one world highest rates ESCC. no previous study has reported tissues from Iran. Materials Methods: In this study, we compared a common marker for presence (MY09/MY11 consensus primers) two markers HPV-16 HPV-18 (respective E6 /E7 38 cases normal biopsied Iranian individuals. Results: 14 out (36.8%) samples, but only 5 control samples (13.2%) were positive presence; difference was statistically significant (p=0.02). Five none HPV16 gene (p=0.05). Three (7.9%) five HPV18 gene. Conclusions: Our data are consistent DNA conducted other high-risk should considered potential factor responsible increased high-incidence world.
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