Antihypertensive Agents and Cardiovascular Risk

摘要: Controlled trials have made it clear that drug treatment reduces the morbidity of hypertensive disease, in severe (51) and mild to moderate hypertension (2,15,19,33,37,46,50,52). There was a reduction frequency stroke, heart failure, encephalopathy, renal dissecting aneurysms but ineffective reducing atherosclerosis or its complications, with two possible exceptions. In MRC study (37) propranolol may reduced myocardial infarction subgroup males who did not smoke. Even if accepts post hoc analysis as reasonable, effect limited. A second exception, elderly, designed avoid thiazide-induced electrolyte disarray, documented death both from disease (2).