Cytotoxic activity of ethanolic extracts of Eleutherococcus species cultivated in Poland on HL60 leukemia cell line

摘要: Received 09 December 2013 Accepted 10 January 2014 The Eleutherococcus species including 40 native to Asia are medicinal plants widely used in traditional medicine. Some of these cultivated at the botanical gardens Europe. On basis on our earlier studies it was concluded that extracts analyzed act as antioxidants, inhibitors MMPs, and cytotoxic against Jurkat 45 leukemia cell line. In this study, anti-leukemic potential roots leaves from six Poland determined. vitro activity towards human promyelotic line HL60 using trypan blue assay evaluated. induction apoptosis stimulated cells determined by AnnexinV method. Morphological changes treated were observed microscopic investigations. results showed ethanolic E. senticosus, setchuensis, sessiliflorus , E.gracilistylus, henryi divaricatus exhibit effect leukemic cells. received IC50 values for ranged 49208 µg/mL 116-518 µg/mL. ethanol extract highest proapoptotic lymphoid