Growth Hormone (GH)-Releasing Peptide Stimulates GH Release in Normal Men and Acts Synergistically with GH-Releasing Hormone*

摘要: The acute GH release stimulated by the synthetic hexapeptide, His-DTrp-Ala-Trp-DPhe-Lys-NH2 [GH releasing peptide (GHRP)], was determined in 18 normal men and compared with effects of GH-releasing hormone, GHRH-(1–44)-NH2. Specificity effect assessed measurement serum PRL, LH, TSH, cortisol. GHRP administered at doses 0.1, 0.3, 1.0 μg/kg iv bolus. GHRH a dose alone together various does GHRP. No adverse clinical or laboratory abnormalities were observed response to A side-effect mild facial flushing 1- 3-min duration occurred 16 subjects who received GHRH-(l–44)-NH2. Mean (±SEM) peak levels after injection ofplacebo 1.2 ± 7.6 2.5, 16.5 4.1, 68.7 15.5 μg/L, respectively. submaximal dosages 0.1 0.3 plus 1 synergistically. Serum PRL cortisol rose about 2-fold above ...