The miR-367-3p Increases Sorafenib Chemotherapy Efficacy to Suppress Hepatocellular Carcinoma Metastasis through Altering the Androgen Receptor Signals.

摘要: The androgen receptor (AR) was found to suppress hepatocellular carcinoma (HCC) metastasis at late stages. Due this discovery, we searched for some AR enhancers increase the efficacy of Sorafenib chemotherapy, and identified microRNA (miR)-367-3p, whose expression is positively correlated with in advanced HCC, as an HCC suppressor. Combining miR-367-3p showed better cell invasion vitro vivo. Mechanism dissection revealed that could via directly targeting 3′UTR MDM2 decrease protein expression. resultant might then promote FKBP5 PHLPP, thus dephosphorylating inactivating AKT ERK, invasion. Interestingly, suppression pAKT by subsequently attenuate phosphorylation MDM2, giving rise additional enhancement expression, effectively forming a positive feedback loop. Together, these results suggest may function enhancer chemotherapy altering MDM2/AR/FKBP5/PHLPP/(pAKT pERK) signals metastasis. Successful development newly combined future help us