Suberoylanilide hydroxamic acid sensitizes neuroblastoma to paclitaxel by inhibiting thioredoxin‐related protein 14‐mediated autophagy
作者： Zijun Zhen , Kaibin Yang , Litong Ye , Zhiyao You , Rirong Chen
DOI: 10.1111/CAS.13279
关键词:
摘要: Paclitaxel is not as effective for neuroblastoma most of the front-line chemotherapeutics due to drug resistance. This study explored regulatory mechanism paclitaxel-associated autophagy and potential solutions paclitaxel resistance in neuroblastoma. The formation autophagic vesicles was detected by scanning transmission electron microscopy flow cytometry. autophagy-associated proteins were assessed western blot. Autophagy induced LC3-I, LC3-II, Beclin 1, thioredoxin-related protein 14 (TRP14), found be up-regulated cells that exposed paclitaxel. inhibition 1 or TRP14 siRNA increased sensitivity tumor In addition, 1-mediated regulated TRP14. Furthermore, inhibitor suberoylanilide hydroxamic acid (SAHA) down-regulated paclitaxel-induced enhanced anticancer effects normal control cancer but with expression. Our findings showed SAHA could sensitize specifically inhibiting TRP14. This article protected copyright. All rights reserved.
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