Innate Immunity to Mucosal Candida Infections

摘要: Mucosal epithelial tissues are exposed to high numbers of microbes, including commensal fungi, and able distinguish between those that avirulent cause disease. Epithelial cells have evolved multiple mechanisms defend against colonization invasion by Candida species. The interplay mucosal immune is key for control clearance fungal infections. Our understanding the innate host defense system has expanded recently with new studies bringing light importance cell responses, T cells, neutrophils, other phagocytes during release cytokines, peptides, alarmins act in concert limit proliferation recruit effector cells. cell/IL-17 axis recruitment neutrophils central controlling Here, we review current knowledge immunity at sites infection, a focus on infections caused C. albicans.